Hunter Biden, the son of President Joe Biden, is expected to plead not guilty to charges of illegally owning a handgun on Tuesday.
Prosecutors allege that Mr Biden, 53, lied about his drug use on application forms when he purchased the weapon in 2018.
Mr Biden has acknowledged that he was a heavy user of crack cocaine at the time, but denies breaking the law.
He faces up to 25 years in prison if convicted of the three federal counts.
A proposed plea deal to resolve the charges abruptly fell apart in July, meaning Mr Biden was indicted shortly after.
He was charged with two counts of making false statements and one count of illegal gun possession. The charges all relate to his purchase of a revolver at a Delaware gun store in October 2018, which he kept for around 11 days.
By Mr Biden’s own admission – published in a 2021 memoir – he was in the throes of a “full-blown addiction” at the time.
Two of the criminal counts against him, each punishable by up to 10 years, stem from the allegations that Mr Biden lied about his drug use on the forms. A third count, related to his possession of a firearm while a drug user, is punishable by up to five years.
In a court filing in September in which his legal team unsuccessfully sought a virtual, not in-person, court appearance, Mr Biden’s attorney, Abbe Lowell, said that his client would enter a plea of not guilty.
He will appear in a federal courthouse in Wilmington, Delaware which is the hometown of the Bidens.
The gun at the centre of the case was found by Hallie Biden, the widow of Hunter’s brother Beau, in his vehicle. Ms Biden threw the weapon into a rubbish bin, reportedly because she feared he might use it to hurt himself.
It was later discovered and returned to the store, but not before it prompted separate investigations by both Delaware police and the US Secret Service.
In June, a two-part agreement was reached between prosecutors and Hunter Biden’s legal team in which he agreed to admit illegal possession of a firearm and undertake addiction treatment and monitoring. Under that agreement, he would also be charged with two misdemeanour counts for failing to pay his taxes on time in 2017 and 2018.
But the deal, which would have allowed Mr Biden to avoid felony charges and potential imprisonment, fell apart in July. The judge in the case, Maryellen Noreika, said she could not “rubber stamp” the agreement. She also called the deal’s proposed resolution of the gun charge “unusual”.
While the tax charges were dismissed in August, prosecutors are expected to refile the charges, or file new ones, in Washington DC or California.
Earlier in September, Mr Biden filed a lawsuit against the Internal Revenue Service, alleging that two of its agents “sought to target and embarrass” him by sharing private tax information.
The case could mean that Hunter Biden faces a criminal trial while his father campaigns for re-election as president.