Three persons have reportedly died after receiving injections at the New Senchi Health Centre at Akrade in the Eastern Region.
Some two others are also in critical condition at the hospital.
The deceased include 78-year-old Bande Yobi, Kwadwo Adjei Kyeremeh, 31 and Eugenia Atsupui Gapher, 42.
A family member of one of the deceased in an interview on Accra-based Citi FM said her uncle died on Monday after reacting to the injection.
She said he had visited the hospital to treat a skin condition and was injected by one of the medical officers.
The Director of Public Health at the Ghana Health Service, Dr Badu Sarkodie has confirmed the deaths and says a team has been dispatched to the medical facility to assess the situation.